Pre-treat with the enzyme solution at full strength. I like to use the glass spray bottle for this. Then use the pet urine odor solution in your shampooer. This machine is SO easy to use I keep it in my hallway closet and use it anytime we have an accident! springcleaning petcare homeinteriors cleanqueen @bissellclean @naturesmiracleproducts LTKFamily LTKPets LTKHome